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The high affinity of GHK for copper(II) ions (binding constant K = 10^16.44 M) ensures that copper is transported in a bound, controlled form rather than as a free ion causing oxidative stress

The 5-LOX enzyme, found in CD163 + tumor-associated macrophages, promotes the formation of hepatocellular carcinoma (HCC) by generating leukotrienes that augment cancer cell proliferation and stem cell capabilities [275]

It is therefore safe to say that the circuitry of the cerebellum has been and still is among the most heavily investigated structures in the entire nervous system